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2021-22 Game Notes
| Opponent | ETSU Notes | Opponent Notes |
| Series 1: Northern Kentucky | ETSU | NKU |
| Midweek 1: Virginia Tech | ETSU | VT |
| Series 2: Wagner | ETSU | |
| Midweek 2: Tennessee | ETSU | UT |
| Series 3: Winthrop | ETSU | |
| Series 4: Rider and UNC-Asheville | ||
| Midweek 3: Radford/Lafayette | ETSU | |
| Series 5: Tennessee Tech | ETSU | |
| Series 6: George Washington | ETSU | |
| Series 7: Baylor | ETSU | BAY |
| Series 8: Western Carolina* | ETSU | |
| Series 9: Wofford* | ETSU | WOF |
| Series 10: VMI* | ||
| Series 11: Mercer* | ||
| Series 12: Samford* | ETSU | SAM |
| Series 13: UNCG* | ETSU | |
| Series 14: The Citadel* | ||
| SoCon Tournament | ETSU |
