Alyssa Sweeney enters her third season with the ETSU women's basketball program in 2023-24, starting in 2021 as a graduate assisant. In July of 2022, she was promoted to Director of Basketball Operations.

In just her second season with the program in 2022-23, ETSU enjoyed the largest turnaround in NCAA Division I Women's Basketball. The program went from a 6-22 record in the 2021-22 season to a 25-10 record in 2022-23 for a 19-win improvement. The improvement is the seventh-best turnaround in NCAA women's basketball history. 

Sweeney was also also part of the ETSU staff while the team set new school records for wins in a season (25) and non-conference wins in a season (13), winning the program's first postseason game since 1995 with two wins in the Women's Basketball Invitational, as well as the team's first College Insider Top 25 Mid-Major ranking since 2010. The Bucs were either ranked or receiving votes for 10 straight weeks (Dec. 20, 2022 - Feb. 21, 2023) and were ranked for three of those (Dec. 27, 2022 - Jan. 10, 2023) while Sweeney handled operations.

Also in Sweeney's first season as DOBO, ETSU set school records for made three-pointers in a single season (228), best margin of victory (69), fewest points allowed in a game (26), fewest points combined (75) in a 44-31 win over Vanderbilt, as well as the single-game three-pointers made record in a win over SoCon regular season champion Wofford (16).

The Bristow, Virginia native spent three seasons at Hampton University, graduating early with honors while also being selected as a member of the Big South All-Academic Team. Sweeney played in 54 games over the course of her three years in Hampton, Va. As a freshman, Sweeney broke out with a career-high 24 points against Mid-Atl. Christian. Sweeney also knocked down 20 points on 8-12 shooting against Longwood in 2019, doing so in just 24 minutes of action.

Prior to her time at Hampton, Sweeney was a four-year varsity member at Stonewall Jackson High School. Helping her team to two district championships, Sweeney was a First Team All-Conference performer while accruing Second Team All-Region accolades, all while being recognized as the top three-point shooter in the DMV area coming out of high school.